LX-2（人肝星狀細胞系）
CBP60648
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| I. General information | |
| Synonyms: | LX-2 |
| Background: | Hepatic stellate cells are a major cell type responsible for liver fibrosis following their activation into fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for human studies. LX-2 was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early passaged cells in low serum media conditions. Immortalized LX-2 was established by Xu et al to overcome issues of culture variability and to provide a stable and unlimited source of human hepatic stellate cells that are homogeneous. These cell lines have been extensively characterized and retain key features of cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis, making them highly suitable for culture based studies of human hepatic fibrosis. |
| Species: | Homo sapiens (Human) |
| Alternate Names： | HSC Perisinusoidal cells Ito cells Hepatic lipocytes Hepatic pericytes |
| Disease: | Normal |
| Culture Medium: |
DMEM+10%FBS LX-2完全培養(yǎng)基，# CBP60648M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Comments: | The LX-2 human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making them a highly suitable model of human hepatic fibrosis. |
