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首頁 /藥靶模型 /藥靶細(xì)胞 /激酶靶點(diǎn) /EGFR S768_V769delinsIL(S768I&V769L)/BaF3

EGFR S768_V769delinsIL(S768I&V769L)/BaF3

CBP73181

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I. Introduction
Cell Line Name: EGFR S768_V769delinsIL(S768I&V769L)/BaF3
Host Cell: Ba/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS+2ug/ml puromycin
Mycoplasma Status: Negative
 
II. Background

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019).

 
III. Representative Data

1. WB of EGFR S768_V769delinsIL(S768I&V769L)/BaF3

2. Anti-proliferation assay


藥靶模型聯(lián)系方式: 華東銷售經(jīng)理:18240630236 全國銷售經(jīng)理:18066071954
診斷標(biāo)準(zhǔn)品聯(lián)系方式: 華東銷售經(jīng)理:15000320447 華北銷售經(jīng)理:18131625521 華南銷售經(jīng)理:13484295986 華中&西南銷售經(jīng)理:13871580511 全國銷售經(jīng)理:13484295986

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