hClaudin 6(CLDN6)/CHO
CBP74181
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| I. Background | |
| CLDNs 是上皮細胞緊密連接的主要成分。CLDN6 是緊密連接家族（CLDNs）的一員，是一個四次跨膜蛋白，具有較短的胞質(zhì) N 端和 C 端胞質(zhì)結(jié)構(gòu)域、兩個胞外結(jié)構(gòu)域（較大的 ECL1 和較小的 ECL2）和一個短的胞內(nèi)環(huán)。CLDN6 可參與乳腺癌、胃癌、肝細胞癌等多種惡性腫瘤的發(fā)生發(fā)展。CLDN6 具有重要的生物學(xué)功能，其異常表達與丙型肝炎感染有關(guān)。 | |
| II. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | Claudin 6(CLDN6) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5ug/ml puromycin |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| IV. Representative Data | |
|
Figure 1.Recombinant CLDN6/CHO constitutively expressing CLDN6. |
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